Platform Patents

Sublingual Delivery

NANOEMULSION DELIVERY SYSTEM – PCT IB2009/055754

A nanoemulsion, which acts as delivery system, consisting of a pool of excipients specifically selected to:
  • solubilise lipophilic molecules, insoluble in aqueous solutions.
  • improve bioavailability of otherwise poorly absorbable molecules.
  • increase the speed of action of the product.
  Dosage form: sublingual oral spray.
  • the high vascularisation of the sublingual mucosa allows faster absorption.
  • intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulati.
  Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.   Examples of application:
  • sublingual spray with vitamin D3, known to contribute to calcium homeostasis and to maintain bone physiological wellbeing.
  • sublingual spray with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

Entric Delivery

ENTEROSOMA – EPO 13723129.6

Pool of excipients contained in gastro-resistant tablets designed to bypass the physiological constraints to intestinal absorption due to:
  • thickness of mucous secretions.
  • cytochrome activity.
  • P-glycoprotein action.
  • proteolytic hydrolysis.
  • low transmucosal flux through tight junctions.
  Dosage form: gastro-resistant tablets. Deliverable active ingredients: raw materials with poor bioavailability in the intestines. Examples of application:
  • formulation in gastro-resistant tablets to deliver berberine, useful for controlling blood sugar levels and cholesterol.
  • formulation in gastro-resistant tablets with curcumin, dry extract with marked anti-inflammatory properties.

PROBUP DROPS™ – Patent pending 102023000026925

Compositions improving probiotics-in-oil’s dispersions.  A pool of substances that stabilizes the product, reducing the formation of aggregates and facilitating the resuspension of probiotics once the liquid is shaken. Dosage form:Oil drops.The new technology resolves the typical Challenges of probiotic oil drops development:
  • Critical organoleptic stability through the Screening to select best ingredients combo for the specific strain(s)
  • Additives are compliant with Infant food regulation
  • Clean label thanks to a short ingredient list and natural components.
  Advantages:
  • Shorter Development Time & Increased Project Success
  • Easier re-suspendable sediment

Topical application

HYDRALAYER™ – patent pending

HYDRALAYER™ is a biomimetic Patented technology for all your topical needs:
  • emulsion characterized by a particular “active” structure: indeed, its multilamellar organization (liquid crystals) reminds the stratum corneum lipid structure.
  • more dermocompatible than a traditional emulsion, thanks to its biomimetic structure.
  • a basic moisturizing cream, suitable for many applications, for sensitive and normal skin.
  • 100% ingredients of natural origin, capable of moisturizing the skin and keeping it hydrated over time.
  • dermatologically tested for sensitive skin.
  • 8 metal tested (Ni, Cr, Co, Hg, As, Cd, Pb, Sb).
  • Allergen free.
  • In vitro and in vivo tested.
By adding different active ingredients, this platform formulation can develop different functional products: