Platform Patents

Sublingual Delivery

NANOEMULSION DELIVERY SYSTEM – PCT IB2009/055754

A nanoemulsion, which acts as delivery system, consisting of a pool of excipients specifically selected to:
  • solubilise lipophilic molecules, insoluble in aqueous solutions.
  • improve bioavailability of otherwise poorly absorbable molecules.
  • increase the speed of action of the product.
  Pharmaceutical form: sublingual oral spray.
  • the high vascularisation of the sublingual mucosa allows faster absorption.
  • intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulati.
  Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.   Examples of application:
  • sublingual spray with vitamin D3, known to contribute to calcium homeostasis and to maintain bone physiological wellbeing.
  • sublingual spray with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

ADSORBED NANOEMULSION SYSTEM – EPO 11727518.0

A delivery system consisting of the adsorbed nanoemulsion delivery system pool of excipients in powder form, made specifically to:
  • deliver lipophilic molecules, improving their solubility once dissolved in the mouth or in water.
  • improve the bioavailability of otherwise poorly absorbable molecules.
  • improve the palatability of the active ingredients with unpleasant taste.
  Pharmaceutical form: oral soluble or water-soluble powder. Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.   Examples of application:
  • water-dispersible powder with coenzyme Q10 to control the oxidation state of the organism.
  • oral soluble powder with resveratrol for the wellbeing of menopausal women.

SUBLINGUAL NANOTABLETS – 102016000022050

A delivery system consisting of the nanoemulsion delivery system pool of excipients in tablet form, made to:
  • deliver lipophilic active molecules, improving their solubility.
  • improve absorption of such substances through the sublingual circulation.
  • dissolve under the tongue after contact with saliva.
  Pharmaceutical form: sublingual tablets.
  • the high vascularisation of the sublingual mucosa allows faster absorption of the active ingredients.
  • intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulation.
  • excellent compliance in use, convenience and taste.
Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver. Examples of application:
  • tablets with resveratrol, vitamin D3 and vitamin E specifically formulated to alleviate menopausal symptoms.
  • tablets with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

Entric Delivery

ENTEROSOMA – EPO 13723129.6

Pool of excipients contained in gastro-resistant tablets designed to bypass the physiological constraints to intestinal absorption due to:
  • thickness of mucous secretions.
  • cytochrome activity.
  • P-glycoprotein action.
  • proteolytic hydrolysis.
  • low transmucosal flux through tight junctions.
  Pharmaceutical form: gastro-resistant tablets. Deliverable active ingredients: raw materials with poor bioavailability in the intestines. Examples of application:
  • formulation in gastro-resistant tablets to deliver berberine, useful for controlling blood sugar levels and cholesterol.
  • formulation in gastro-resistant tablets with curcumin, dry extract with marked anti-inflammatory properties.

LIPOMATRIX – 102016000059138

Technology developed to deliver lipid components in tablet form, exploiting the natural gastro-resistance of the active ingredients. Pharmaceutical form: gastro-resistant tablets and powders. Deliverable active ingredients: lipophilic or oily substances.   Examples of application:
  • formulations with boswellia resin and vitamin D3, useful for their action on joint function and as promoter of calcium absorption into the bones respectively.
  • formulations with serenoa oil, useful for correct functioning of the prostate and urinary tracts.
  • formulations with ginger oil to relieve nausea.

Topical application

HYDRALAYER™ – patent pending

HYDRALAYER™ is a biomimetic Patented technology for all your topical needs:
  • emulsion characterized by a particular “active” structure: indeed, its multilamellar organization (liquid crystals) reminds the stratum corneum lipid structure.
  • more dermocompatible than a traditional emulsion, thanks to its biomimetic structure.
  • a basic moisturizing cream, suitable for many applications, for sensitive and normal skin.
  • 100% ingredients of natural origin, capable of moisturizing the skin and keeping it hydrated over time.
  • dermatologically tested for sensitive skin.
  • 8 metal tested (Ni, Cr, Co, Hg, As, Cd, Pb, Sb).
  • Allergen free.
  • In vitro and in vivo tested.
By adding different active ingredients, this platform formulation can develop different functional products: