Delivery Patents

Sublingual Delivery

NANOEMULSION DELIVERY SYSTEM – PCT IB2009/055754

A nanoemulsion, which acts as delivery system, consisting of a pool of excipients specifically selected to:

  • solubilise lipophilic molecules, insoluble in aqueous solutions.
  • improve bioavailability of otherwise poorly absorbable molecules.
  • increase the speed of action of the product.

Pharmaceutical form: sublingual oral spray.

  • the high vascularisation of the sublingual mucosa allows faster absorption.
  • intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulati.

Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.


Examples of application:

  • sublingual spray with vitamin D3, known to contribute to calcium homeostasis and to maintain bone physiological wellbeing.
  • sublingual spray with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

ADSORBED NANOEMULSION DELIVERY SYSTEM – EPO 11727518.0

A delivery system consisting of the adsorbed nanoemulsion delivery system pool of excipients in powder form, made specifically to:

  • deliver lipophilic molecules, improving their solubility once dissolved in the mouth or in water.
  • improve the bioavailability of otherwise poorly absorbable molecules.
  • improve the palatability of the active ingredients with unpleasant taste.

Pharmaceutical form: oral soluble or water-soluble powder.


Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.


Examples of application:

  • water-dispersible powder with coenzyme Q10 to control the oxidation state of the organism.
  • oral soluble powder with resveratrol for the wellbeing of menopausal women.

SUBLINGUAL NANOTABLETS – 102016000022050

A delivery system consisting of the nanoemulsion delivery system pool of excipients in tablet form, made to:

  • deliver lipophilic active molecules, improving their solubility.
  • improve absorption of such substances through the sublingual circulation.
  • dissolve under the tongue after contact with saliva.

Pharmaceutical form: sublingual tablets.

  • the high vascularisation of the sublingual mucosa allows faster absorption of the active ingredients.
  • intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulation.
  • excellent compliance in use, convenience and taste.

Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.


Examples of application:

  • tablets with resveratrol, vitamin D3 and vitamin E specifically formulated to alleviate menopausal symptoms.
  • tablets with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

Probiotics

SELF-EMULSIFYING ANHYDROUS DISPERSION SYSTEM – PCT IT2009/000373

An oily liquid carrier which guarantees the survival of the probiotics and increases their stability. The advantages are:

  • an effective quantity of live cells are released (up to 1 billion CFU per drop).
  • a completely anhydrous environment is created, suitable for the survival of micro-organisms.
  • a stable, ready-to-use product is created without the addition of other excipients.

Pharmaceutical form: drops in oil. Easy to administer to children, suitable for mixing with water or other liquids, ideal not only for children but also adults and the elderly.


Deliverable active ingredients: probiotics, such as lactobacilli, bifidobacteria.


Applications: oily drops with L. rhamnosus GG, useful for maintaining eubiosis.

REW CAP

Vial with patented container cap for the administration of probiotics and unstable substances. Its advantages are:

  • it protects the probiotics against humidity.
  • it prolongs the stability of the probiotics.
  • it delivers high quantities of active ingredients.
  • it is practical to administer to children and outside the home.

In the cap: high quantities (up to 1g) of active ingredients in powder, protected against humidity thanks to a layer of silica micro-granules with desiccant properties.


In the vial: liquid in which active ingredients are dispersed.


Examples of application:

  • product with probiotics (in the cap) and prebiotics (in the vial) for eubiosis.
  • product with amino acids (in the cap) and vegetable extracts (in the vial) for enhancing sport performance.
  • product with lipophilic vitamins (in the cap) and hydrophilic vitamins (in the vial) for a complete vitamin supplement.

Enteric Delivery

ENTEROSOMA – EPO 13723129.6

Pool of excipients contained in gastro-resistant tablets designed to bypass the physiological constraints to intestinal absorption due to:

  • thickness of mucous secretions.
  • cytochrome activity.
  • P-glycoprotein action.
  • proteolytic hydrolysis.
  • low transmucosal flux through tight junctions.

Pharmaceutical form: gastro-resistant tablets.


Deliverable active ingredients: raw materials with poor bioavailability in the intestines.


Examples of application:

  • formulation in gastro-resistant tablets to deliver berberine, useful for controlling blood sugar levels and cholesterol.
  • formulation in gastro-resistant tablets with curcumin, dry extract with marked anti-inflammatory properties.

LIPOMATRIX – 102016000059138

Technology developed to deliver lipid components in tablet form, exploiting the natural gastro-resistance of the active ingredients.


Pharmaceutical form: gastro-resistant tablets and powders.


Deliverable active ingredients: lipophilic or oily substances.


Examples of application:

  • formulations with boswellia resin and vitamin D3, useful for their action on joint function and as promoter of calcium absorption into the bones respectively.
  • formulations with serenoa oil, useful for correct functioning of the prostate and urinary tracts.
  • formulations with ginger oil to relieve nausea.

Liquids

NATURAL DEEP EUTECTIC SOLVENTS – (NADES) MI2012A000847

Technology that exploits the eutectic properties of certain substances, which when mixed create anhydrous liquids. Designed to:

  • allow the delivery in liquid form of substances that are insoluble or unstable in water.
  • increase the bioavailability.
  • avoid the use of preservatives.

Pharmaceutical form: drinkable liquid.


Deliverable active ingredients: active ingredients either unstable or insoluble in water.


Examples of application:

  • liquid formulation with luteolin and zinc specifically formulated for ocular wellbeing.
  • liquid formulation with vitamin C to strengthen the body’s defences.

IONIZED WATER – A.I.D.

An innovative transportation system which combines the simplicity and naturalness of water with cutting-edge technologies to allow better absorption of the active ingredients. Its advantages are:

  • it acts as absorption booster for functional active ingredients.
  • its versatility: effective for both topical and systemic use.

Pharmaceutical form: liquid, gel or cream.


Deliverable active ingredients: many, for both topical application and systemic intake.


Examples of application:

  • topical products in which the presence of A.I.D. enables cutaneous absorption of the delivered active ingredients to be enhanced, for example aloe with a soothing, moisturising action on the skin.
  • formulations with amino acids specifically formulated to support the physical activity of athletes before, during and after the actual activity.