NANOEMULSION DELIVERY SYSTEM – PCT IB2009/055754

A nanoemulsion, which acts as delivery system, consisting of a pool of excipients specifically selected to:

• solubilise lipophilic molecules, insoluble in aqueous solutions.
• improve bioavailability of otherwise poorly absorbable molecules.
• increase the speed of action of the product.

Pharmaceutical form: sublingual oral spray.

• the high vascularisation of the sublingual mucosa allows faster absorption.
• intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulati.

Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.

Examples of application:

• sublingual spray with vitamin D3, known to contribute to calcium homeostasis and to maintain bone physiological wellbeing.
• sublingual spray with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

SUBLINGUAL NANOTABLETS – 102016000022050

A delivery system consisting of the nanoemulsion delivery system pool of excipients in tablet form, made to:

• deliver lipophilic active molecules, improving their solubility.
• improve absorption of such substances through the sublingual circulation.
• dissolve under the tongue after contact with saliva.

Pharmaceutical form: sublingual tablets.

• the high vascularisation of the sublingual mucosa allows faster absorption of the active ingredients.
• intestinal absorption is bypassed, thereby avoiding first-pass effect in the hepatic circulation.
• excellent compliance in use, convenience and taste.

Deliverable active ingredients: poorly bioavailable lipophilic substances, metabolised in the liver.

Examples of application:

• tablets with resveratrol, vitamin D3 and vitamin E specifically formulated to alleviate menopausal symptoms.
• tablets with melatonin, useful for alleviating sleep disorders (jet lag, insomnia).

REW CAP

Vial with patented container cap for the administration of probiotics and unstable substances. Its advantages are:

• it protects the probiotics against humidity.
• it prolongs the stability of the probiotics.
• it delivers high quantities of active ingredients.
• it is practical to administer to children and outside the home.

In the cap: high quantities (up to 1g) of active ingredients in powder, protected against humidity thanks to a layer of silica micro-granules with desiccant properties.

In the vial: liquid in which active ingredients are dispersed.

Examples of application:

• product with probiotics (in the cap) and prebiotics (in the vial) for eubiosis.
• product with amino acids (in the cap) and vegetable extracts (in the vial) for enhancing sport performance.
• product with lipophilic vitamins (in the cap) and hydrophilic vitamins (in the vial) for a complete vitamin supplement.

LIPOMATRIX – 102016000059138

Technology developed to deliver lipid components in tablet form, exploiting the natural gastro-resistance of the active ingredients.

Pharmaceutical form: gastro-resistant tablets and powders.

Deliverable active ingredients: lipophilic or oily substances.

Examples of application:

• formulations with boswellia resin and vitamin D3, useful for their action on joint function and as promoter of calcium absorption into the bones respectively.
• formulations with serenoa oil, useful for correct functioning of the prostate and urinary tracts.
• formulations with ginger oil to relieve nausea.

IONIZED WATER – A.I.D.

An innovative transportation system which combines the simplicity and naturalness of water with cutting-edge technologies to allow better absorption of the active ingredients. Its advantages are:

• it acts as absorption booster for functional active ingredients.
• its versatility: effective for both topical and systemic use.

Pharmaceutical form: liquid, gel or cream.

Deliverable active ingredients: many, for both topical application and systemic intake.

Examples of application:

• topical products in which the presence of A.I.D. enables cutaneous absorption of the delivered active ingredients to be enhanced, for example aloe with a soothing, moisturising action on the skin.
• formulations with amino acids specifically formulated to support the physical activity of athletes before, during and after the actual activity.